complement activation การใช้

• The binding of XNAs initiate complement activation through the classical complement pathway.
• Antibodies are produced against the RBCs, which leads to complement activation.
• Complement activation is very important in acute proliferative glomerulonephritis.
• Classical complement activation has also been shown to combat Methicillin-resistant Staphylococcus aureus.
• There is no complement activation or MAG loss.
• Eculizumab inhibits terminal complement activation and therefore makes patients vulnerable to infection with encapsulated organisms.
• In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis.
• Figure 2 shows the classical and the alternative pathways with the late steps of complement activation schematically.
• Due to its polymeric nature, IgM possesses high avidity, and is particularly effective at complement activation.
• This newly bound C3b recruits more B, D and P activity and greatly amplifies the complement activation.
• Immunotherapies have been developed to detect and destroy cells infected by the HIV virus via classical complement activation.
• Warm-type AIHA shows a positive reaction with antisera to IgG antibodies with or without complement activation.
• C4d is a complement split product, inactivated c4b, and reflects complement activation by the classical pathway.
• MASP-1 is a serine protease that functions as a component of the lectin pathway of complement activation.
• Both of these disorders are currently thought to be due to aberrant complement activation on the surface of host cells.
• Susceptibility to bacterial infections probably results from a C3 deficiency ( due to complement activation and consumption of C3 ).
• Therapies that utilize classical complement activation have been shown to be effective in targeting and killing cancer cells and destroying tumors.
• Factor I deficiency in turn leads to low levels of Haemolytic Uremic Syndrome, a renal disease also caused by unregulated complement activation.
• "' Factor H "'is a member of the regulators of complement activation family and is a complement control protein.
• SpeB degrades immunoglobulins and cytokines, as well as through cleavage of C3b, inhibiting recruitment of phagocytic cells and the complement activation pathway.